What (Hydroxy)chloroquine Does To The Body



These cases are patients who I, or my colleagues have seen. They are de-identified and many instances have been presented in more depth in an academic setting. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet, see your own physician in person for that.

[0] Treatment of Severe Chloroquine Poisoning. New England Journal Of Medicine 1988; 318:1-6.

[1] Hydroxychloroquine is much less active than chloroquine against chloroquine-resistant Plasmodium falciparum, in agreement with its physicochemical properties. J Antimicrob Chemother. 2003;52(2):188.

[2] Antimalarial toxicity: a review. https://www.ncbi.nlm.nih.gov/pubmed?t…

[3] Single IV delivery of chloroquine in the treatment of falciparum malaria: toxicity and immediate therapeutic effects in 110 cases. Am J Trop Med Hyg. 1950;30(4):503.

[4] Taking the “idio” out of “idiosyncratic”: predicting torsades de pointes. Pacing Clin Electrophysiol. 1998;21(5):1029.

[5] The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines. FASEB J. 2003;17(15):2263.

[6] Extracellular potassium modulation of drug block of IKr. Implications for torsade de pointes and reverse use-dependence. Circulation. 1996;93(3):407.

[7] Erythromycin blocks the rapid component of the delayed rectifier potassium current and lengthens repolarization of guinea pig ventricular myocytes. Circulation. 1995;91(12):3010.

[8] The mechanism of toxicity from quinidine and a method of resuscitation: an experimental study . J Clin Invest 1925; 1:497–517.

[9] Chloroquine toxicity. Br J Clin Pharmacol 1983; 15:502–3.

[10] Chloroquine intoxication: two case reports . Forensic Sci Int 1978; 11:177–9.

[11] Experimental assessment of the protecting activity of diazepam on the acute toxicity of chloroquine . J Toxicol Clin Toxicol 1983; 20:271–9.

[12] Treatment of chloroquine poisoning with diazepam: preliminary results of an experimental study. Intensive Care Med 1986.


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